Future COVID variants are anticipated to be extra transmissible and maybe higher at evading the immune system. And they may even render remedies for sufferers like monoclonal antibodies “less effective,” the World Health Organization’s pandemic lead mentioned Thursday.

“We’re still at risk for future variants, and we don’t know what the character” of these variants might be, Dr. Maria Van Kerkhove, the WHO’s technical lead for COVID-19, mentioned at a information convention

Van Kerkhove mentioned that the WHO is keeping track of Omicron variants BA.5—presently dominant globally—and its descendents, along with BA.2.75, also referred to as “Centaurus,” and its spawn, BA.2.75.2, amongst others.

The worldwide well being group is monitoring about 200 Omicron subvariants, she mentioned, including that the virus “continues to circulate at an incredibly intense level around the world.”

Already a handful of these variants have been flagged by specialists as having the potential to trigger, or at the very least contribute to, a COVID wave this fall and winter.

And one—BA.2.75.2—is especially regarding for its potential to thwart the final monoclonal antibody therapy left within the COVID arsenal: Bebtelovimab.

Monoclonal antibody remedies, given to sufferers through infusion at a medical facility after they take a look at constructive, can block a virus from coming into cells, and, thus, could restrict the quantity of viral unfold in a single’s physique. Other related COVID remedies like REGEN-COV have been sidelined as a result of they’ve been discovered ineffective against Omicron.

“For the immunocompromised right now, having monoclonal antibodies is one of the best ways to mitigate infections,” Dr. Raj Rajnarayanan, assistant dean of analysis and affiliate professor on the New York Institute of Technology campus in Jonesboro, Ark., instructed Fortune earlier this week.

“If you take the tool away, it’s going to be a problem.”

It’s unknown precisely how efficient the brand new Omicron boosters is perhaps in opposition to BA.2.75.2, in the event that they’re efficient in any respect.

But a new paper launched this week by researchers on the Imperial College in London and the Karolinska Institute in Sweden highlights the brand new pressure’s “extensive escape” capability. It referred to as the Centaurus spawn “the most neutralization-resistant variant evaluated to date,” and mentioned it might additionally successfully evade immunity constructed by vaccination and prior an infection.
Dr. Anthony Fauci, the nation’s main infectious illness skilled, mentioned in an interview this week that BA.2.75.2 seems “suspicious that it might start to evolve as another variant” of concern, when discussing strains with the potential to gas a fall wave.

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